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Making a hospital visit fun for an eight-year-old is not easy, but Prasanna Shirol and his wife Sharada know a thing or two about it — after all, they did it multiple times for their daughter, Nidhi, who required enzyme-replacement therapy that involved an infusion of drugs lasting 10 to 12 hours every fortnight. In , when she was seven years old, Nidhi was diagnosed with Pompe, an inherited genetic metabolic disorder that affects 1 in 40, people. Her hospital treatments kept her metabolism functioning almost normally and afforded her a good quality of life for 10 years. In , when she was 17, Nidhi fell into a coma after her ventilator failed while she was attending a college event. Prasanna Shirol used his experience accompanying his daughter for lengthy medical treatments to help establish rare disease centres in hospitals across India Like many rare disease advocates, he wants a national policy for rare diseases to fund genetic counselling for high-risk parents, treatment and supportive care.
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Build a Modern Computer from First Principles: From Nand to Tetris (Project-Centered Course)

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In the process, you will learn - in the most direct and constructive way - how computers work, and how they are designed. Therefore, we assume no previous computer science or engineering knowledge, and all learners are welcome aboard. You will need no physical materials, since you will build the computer on your own PC, using a software-based hardware simulator, just like real computers are designed by computer engineers in the field. The hardware simulator, as well as other software tools, will be supplied freely after you enroll in the course. Course format: The course consists of six modules, each comprising a series of video lectures, and a project.
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